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Sad news for fans of The Simpsons, show co-creator Sam Simon succumbed to colon cancer Sunday (March 8). He was 59. 

Reports TMZ:

Simon passed away Sunday at his L.A. home, following a long, difficult battle with colon cancer. Simon was diagnosed in 2012 and was very public that his disease was terminal.

We’re told Simon was surrounded by his family when he died, and his dog. The dog was very special in Sam’s life … he was a big animal rights advocate.

The Sam Simon Foundation tells us, “For those of us who knew him, his voice will forever echo in our minds; his sense of humor will continue to make us laugh; and his compassion and generosity will continue to impact our lives.”

Adding, “Sam, you will be missed by many, but there is a particular sadness among our clinic staff. We have been together for so long, and your absence will forever leave a void in our lives.”

Simon vowed to donate his $100 million fortune to various charities of interest. “I think that my passion for the animals and against animal abuse is based on the knowledge that these creatures who feel and think can’t speak for themselves and they’re dependent on us for that,” he said in an interview. “And so I feel it’s my responsibility to speak for those that can’t speak for themselves.”

Photo: WENN