3. Cleveland, OH
Population Change 2000-2009: -45,205
Population Percent Change 2000-2009: -9.49%
Home Vacancy: 17.5%
The decline of industrial American has hit the city particularly hard, and poverty, a default on municipal debt in the 70′s, and pollution have earned the city the nickname “the mistake on the lake.” In 1948, the city had over 910,000 people; it now has less than half of that.