1. New Orleans, LA
Population Change 2000-2009: -128,813
Population Percent Change 2000-2009: -26.63%
Home Vacancy: 21.5%
The period of widespread homelessness, severe crime, and slow recovery has left the city as a shadow of its former self. While people are trickling back into the city, many will likely never return, and the city has lost more than a quarter of its population in just ten years.